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NEW QUESTION: 1
Your patient is a 58-year-old male who presents with onset of severe substernal chest pain and shortness of breath. An ECG reveals an acute STEMI, and he is on his way to the cardiac catheterization suite for percutaneous coronary intervention.
Which of the following drugs used in acute coronary syndromes treated with PCI must undergo oxidation by hepatic P450 enzymes to an active form?
A. Warfarin
B. Eptifibatide
C. Aspirin
D. Clopidogrel
E. Ticlopidine
Answer: D
Explanation:
Explanation
Clopidogrel and ticlopidine are ADP receptor pathway inhibitors. The irreversible inhibition of the ADP- dependent pathway of platelet activation is thought to be the result of covalent modification and inactivation of the platelet P2Y ADP receptor. This receptor is coupled to the inhibition of adenylyl cyclase. Both drugs are prodrugs and undergo conversion to active metabolites in the liver. However, clopidogrel must undergo oxidation by hepatic P450 enzymes to its active form. This is significant because many drugs are metabolized the hepatic P450 enzymes, including statins, and clopidogrel may interact with these medications. Clopidogrel is a second-generation thienopyridine and ticlopidine is a first-generation thienopyridine. Both drugs are indicated in combination with aspirin to prevent stent thrombosis. Eptifibatide is a GPIIb-IIIa receptor antagonist that is used to treat unstable angina and non-ST segment elevation myocardial infarction.
Eptifibatide is also used to reduce ischemic events in patients who are undergoing percutaneous coronary intervention. The drug is a synthetic peptide that directly antagonizes the GPIIb-IIIa receptor on the platelet.
Aspirin is an antiplatelet drug that works by inhibition of synthesis of prostaglandins. Prostaglandin G2 is the result of a synthesis pathway that is activated by platelets and endothelial cells, and results in localized vasoconstriction and induction of platelet aggregation, as well as causing release of platelet granules. Warfarin is an anticoagulant that acts on vitamin K-dependent reactions in the coagulation pathway. Vitamin K is necessary for hepatic synthesis of coagulation factors II, VII, IX and X, protein C and protein S.
Vitamin K- dependent carboxylation is necessary for induction of enzymatic activity of these coagulation factors. Take- home message: Clopidogrel, a second-generation thienopyridine ADP receptor pathway inhibitor, is indicated in combination with aspirin to prevent stent thrombosis in patients who undergo percutaneous coronary intervention after myocardial infarction. Clopidogrel is a prodrug that must undergo oxidation by hepatic P450 enzymes, and therefore may affect the activity of statins and other drugs dependent on the hepatic P450 enzymes.
NEW QUESTION: 2
Employee 1 needs to set up the new items for the product line
Which two actions should Employee1 perform? Each correct answer presents part of the solution.
NOTE Each correct selection is worth one point.
A. Create new finished goods and release to the legal entity. Raw material products are not required for these items.
B. Create new raw materials and release to the legal entity.
C. Create new finished goods and release to the legal entity
D. Create new finished goods with predefined variants and release to the legal entity.
E. Create new raw materials with variants and release to the legal entity.
Answer: D,E
Explanation:
Topic 1, Organics Company
Background
Best for You Organics Company started as a home-based business. The founders began making handmade soaps and bath products in their kitchen As sales increased, the business established a production facility and distribution center that supplies three retail stores.
Soaps and bath products are manufactured in the production facility and are stocked in the warehouse for distribution to the retail stores. Employees at retail stores use mobile point of sale (MPOS) tablet devices to sell the products to customers.
The company structure is a single legal entity with two sites as shown In the diagram below:
Current environment
Best for You Organics plans to introduce a new product line of face creams. Each product in the new line uses the same base ingredients but includes a different extract (for example, lime, avocado, kiwi). The marketing department is preparing to introduce the new product line. Minimal inventory will be held in the warehouse.
The company uses a cloud-based deployment of Dynamics 365 Supply Chain Management to manage finances for all company operations and locations. The company does not use Bill of Materials (BOM) versioning.
The production and warehouse facility is set up with the following organizational hierarchy:
External customers include:
* Customer A: a walk-in store customer (business-to-consumer)
* Customers: a customer with an existing account (business-to-business) External vendors include:
* VendorA a trucking company
* VendorB: a raw materials supplier
General
The new product line must be set up in the system and readily available for sale when the company introduces the product line to the public at an upcoming trade show.
Production
You must configure the system to produce the new products:
* Ensure that the warehouse stocks the minimum quantities of raw materials to produce the products,
* Use a single version per item.
* Implement FIFO inventory valuation methods.
* Track raw and finished goods using different General ledger accounts.
* Use a primary location to determine where to stock product in the warehouse.
* Configure alternate locations in the warehouse to hold overstock products and refill the primary location as-needed.
Shipments
You identify the following requirements related to shipping:
* Ship product to retail stores weekly.
* Stores require a packing slip to check in merchandise. Drivers require transport documentation and charge per mile to the stores.
* Shipments to Store1 must be scheduled for Monday. Wednesday, or Friday, Store1 will sometimes pick up their own deliveries when an order is small because they have their own van Shipments to Store2 and Store3 must be scheduled for Tuesday or Thursday.
* You must transmit Advance Shipping Notifications (ASNs) to the stores prior to deliveries.
* Set up the system configuration to allow for store transfers.
* Set up the system so that products may be shipped to the retail stores as bulk orders.
* Set up the transport providers to deliver products from the warehouse to the retails stores.
Reporting
Once the new products are available in stores, review 30 days of historical sales data from day-to-day transactions will determine the reorder quantities. Set up reporting to allow the product line to be costed and tracked independent of other items.
Pricing and inventory
You identify the following requirements related to pricing and inventory:
* Determine the Quantity of the new products that can be produced and ready for sale within the first 90 days. Ensure that specialty packaging is on hand for retail sales. The packaging must be shipped directly to the stores from the vendor.
* Stores must not inventory the packaging materials. Stores must maintain a 50-day supply of specialty packaging materials. Stores must reorder packaging materials as needed.
* Retail store customers must pay full retail price, Resellers must receive a 10 percent discount off the list price.
NEW QUESTION: 3
次のうち、マスターデータの特性について説明してください。 （2つ選択）
A. マスタデータは、複数のビジネスプロセスで長期的に使用されます。
B. マスタデータは、トランザクションデータのテンプレートです。
C. マスタデータは作成後に変更できません。
D. 通常、マスターデータは組織レベルに割り当てられます。
E. マスタデータは会社コードレベルで割り当てる必要があります。
Answer: A,D
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